Benefits of custom-made blood vessels
Three dialysis patients have received the world’s first blood vessels grown in a lab from donated skin cells. It’s a key step toward creating a supply of ready-to-use arteries and veins that could be used to treat diabetics, soldiers with damaged limbs, people having heart bypass surgery and others.
The goal is to one day have a refrigerated inventory of blood vessels in various sizes and shapes that surgeons could order up as needed, like bandages and other medical supplies.
The work so far is still early-stage. Three patients in
But doctors are excited because this builds on earlier success in about a dozen patients given blood vessels grown in the lab from their own skin — a process too long and expensive to be practical.
“This version, built from a master donor, is available off the shelf and at a dramatically reduced cost,” estimated at $6,000 to $10,000, said Todd McAllister, chief of Cytograft Tissue Engineering Inc., the San Francisco-area company leading the work.
The American Heart Association considers it so promising that the group featured it in the first of a new series of webcasts about cutting-edge science.
“This is tremendously exciting,” said
Could solve common problem
Kidney failure, which is common in diabetics, requires dialysis to filter wastes from the blood through a connection between an artery and a vein called a shunt.
The shunt gets punctured several times a week to hook patients up to the dialysis machine, and complications include blood clots, clogging and infection. What’s more, patients often run out of suitable sites for these shunts as problems develop.
Each year, nearly 400,000 Americans undergo dialysis and half of them use plastic shunts. Plastic versions have high rates of failure and complications. Doctors have long wished for a natural substitute.
In 2005, Cytograft reported success with its first attempt at dialysis shunts using patients’ own skin. Some of the early work was sponsored by the National Heart, Lung and Blood Institute.
The new work, using donor cells, makes this advance more practical for wide use, said Dr. Timothy Gardner, a heart surgeon at Christiana Care Health Services in
“It provides the option or the opportunity for off-the-shelf graft availability as opposed to something that has to be built from the individual’s own cells,” he said.
Cytograft plans a study in Europe and
How they’re made
The lab-grown vessels are free of artificial materials. They don’t involve stem cells, so they’re not controversial.
Researchers start with a snip of skin from the back of a hand, remove cells and grow them into sheets of tissue that are rolled up like straws to form blood vessels.
So far, these lab-grown vessels have been tolerated by the recipients’ immune systems; no anti-rejection medicine or tissue matching is needed. That’s not surprising because lab-grown skin is already used to treat many burn victims.
“There are literally hundreds of thousands of patients that could use this technology,” McAllister said.
More than 160,000 people lose limbs because of poor circulation that might be improved with lab-grown vessels.
About 300,000 people have heart bypass operations using blood vessels taken from other parts of the body to create detours around clogged heart arteries. Some heart patients say the leg wound from removing the long vein to create heart bypasses hurts more than the chest wound for the open-heart surgery.
For more about Cytograft and a video about how the vessels are made, see www.cytograft.com. — AP