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A yearlong study offers rigorous new evidence against using prescription opioids for chronic pain.

In patients with stubborn back aches or arthritis of the hip or knee, opioids worked no better than over-the-counter drugs or other non-opioids at reducing problems with walking or sleeping. And they provided slightly less pain relief.

Opioids tested included generic Vicodin, oxycodone or fentanyl patches, although few patients needed the most potent opioids. Non-opioids included generic Tylenol, ibuprofen and prescription pills for nerve or muscle pain.

The study randomly assigned patients to take opioids or other painkillers. That’s the gold standard design for research.

If opioids don’t work better than less risky drugs, there’s no reason to use them, given “their really nasty side effects — death and addiction,” said lead author Dr. Erin Krebs, a physician and researcher with the Minneapolis Veterans Affairs Health Care System.

Surprising findings

The results likely will surprise many people “because opioids have this reputation as being really powerful painkillers, and that is not what we found,” Krebs said.

The results echo less rigorous studies and bolster guidelines against routine use of opioids for chronic pain. The study was published in the Journal of the American Medical Association.

About 42,000 drug overdose deaths in the U.S. in 2016 involved opioids, including prescription painkillers, heroin and fentanyl. Many people get hooked while taking opioids prescribed for injuries or other short-term pain, and move on to cheaper, more accessible illicit drugs like heroin.

Krebs said the strongest evidence from other studies shows that physical therapy, exercise or rehabilitation therapy works best for chronic pain. And she said noted that there are a variety of non-opioid drugs to try if one type doesn’t work for someone.

U.S. government guidelines in 2016 said opioids are not the preferred treatment for chronic pain, and they recommend non-drug treatment or non-opioid painkillers instead. Opioids should only be used if other methods don’t work for chronic pain, the guidelines say. Prescribing rates have declined slightly in recent years, although they are still much higher than two decades ago.

Veterans studied

The study involved 234 patients from Minneapolis-area VA clinics who were assigned to use generic versions of opioids or non-opioids for a year. Follow-up ended in 2016.

“This is a very important study,” said Dr. David Reuben, geriatrics chief at UCLA’s medical school. “It will likely change the approach to managing long-term back, hip and knee pain.”

He noted one limitation — most study participants were men. But Krebs said the results in women studied were similar.

The study’s opioid patients started on relatively low daily doses of morphine, oxycodone or generic Vicodin. They switched to higher doses if needed, or to long-acting opioids or fentanyl patches.

The non-opioid group started on acetaminophen, ibuprofen or similar anti-inflammatory drugs. They also could switch to higher doses or prescription non-opioid pain pills. Few in either group used the strongest medicines.

Patients reported changes in function or pain on questionnaires. Function scores improved in each group by about two points on an 11-point scale, where higher scores meant worse function. Both groups started out with average pain and function scores of about 5.5 points.

Pain intensity dropped about two points in the non-opioid group and slightly less in the opioid patients.

Other research has also shown that over-the-counter medicines can work as well as opioids at treating short-term pain, including from broken bones, kidney stones or dental work.

— AP