Drug interactions with foods and drinks

It is important that you review your prescriptions, and other over-the-counter medications and supplements, with your health care provider or pharmacist to determine any potential interactions or reactions. Dreamstime/TNS

By Katherine Zeratsky, R.D.N.
Posted on May 17, 2023

Dear Mayo Clinic: I’ve heard I should avoid certain foods like grapefruit and broccoli, as well as alcoholic beverages, when taking certain medications. Why is that? How can I be safe from any potential issues?

A: Certain foods and beverages can interfere with several kinds of prescription and nonprescription medications.

Problems arise because natural chemicals or nutrients in foods or drinks can interfere with a medication, either lessening its effectiveness or potentially having a stronger effect.

Foods or beverages also can affect the enzymes that break down, or metabolize, the medication in your body. As a result, the medication may stay in your body for too short or too long a time.

A medication that’s broken down too quickly won’t have time to work. On the other hand, a medication that stays in the body too long may build up to potentially dangerous levels.

Don’t take these interactions lightly. Some can cause potentially dangerous health problems. Common and serious side effects are high blood pressure, heart irregularities, muscle weakness and bleeding.

It is important that you review your prescriptions, and other over-the-counter medications and supplements, with your healthcare provider or pharmacist to determine any potential interactions or reactions.

Before taking any medication, it is best to ask, “Are there foods or beverages I should avoid when taking this medication or supplement?”

Another important question to ask your healthcare provider or pharmacist is about the amount, as well as when you can eat certain foods or drink certain beverages. Consider asking if you should completely avoid specific foods or beverages, or if smaller amounts are allowed.

Also, timing can matter. Some medications should be taken with food, while others should be taken on an empty stomach.

Ask about the time difference between ingesting food and taking your medications. Some require a 30- to 60-minute buffer, while other medications may be such that it would simply be best to avoid eating certain foods while taking the prescription.

Foods that commonly interact

These are some of the most common foods and drinks that can cause challenges:

Certain fruits and their juices, such as grapefruit, oranges, pomelos and cranberries
Some vegetables that are rich in vitamin K, such as collards, spinach and kale, and other foods, such as soybeans, broccoli, and carrot and pomegranate juice
Tyramine, which is an amino acid (protein building block) found in pickled and fermented foods, such as sauerkraut and kimchi; processed meats, such as sausages; aged cheese, and some sauces, like shrimp or soy sauce
Licorice or licorice extract in candy or teas
Milk and milk products
Alcoholic and nonalcoholic beverages, such as beer, wine and spirits, and those that contain caffeine, such as coffee, tea or soda.

It is important to be mindful about reading labels and being aware of what ingredients are in certain foods and drinks. Sometimes manufacturers don’t list all the ingredients or use the most common name of an ingredient.

For instance, numerous citrus-flavored soft drinks contain grapefruit juice or grapefruit extract, so if you don’t pay attention, you could have a potential problem with your medications.

If your diet changes seasonally or when away from home — for instance, if you harvest vegetables from a garden, or eat more of certain fruits while on vacation — be thoughtful to ensure consistency with food intake and medication dosing.

Meds that commonly interact

The list of commonly prescribed medications that can interact with certain foods and beverages includes medications that:

Fight infection
Reduce cholesterol
Treat high blood pressure
Treat heart problems
Prevent organ rejection
Treat anxiety or depression
Stabilize mood or act as a stimulant
Control seizures
Minimize motion sickness
Treat erectile dysfunction
Replace hormones
Reduce cough
Control pain

Your health is important. As part of your health, eating a nutritious diet and taking your medications as prescribed matters.

You may be surprised and disappointed to see some of your favorite foods and drinks listed as ones to be wary of when taking different medications. But taking the time to speak with your healthcare provider about the risks and benefits is valuable in the long run to avoid any issues.

If you find it difficult to avoid some of these foods, especially if they are healthy favorites, ask your healthcare provider or pharmacist if comparable medications are available that you can take without interacting with your preferred foods and beverages.

—Katherine Zeratsky, R.D.N., Endocrinology/Nutrition, Mayo Clinic, Rochester, Minnesota.

Mayo Clinic Q & A is an educational resource and doesn’t replace regular medical care. Email a question to MayoClinicQ&A@mayo.edu. For more information, visit mayoclinic.org.